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In this post,  Phil Corlett , Associate Professor of Psychiatry at Yale School of Medicine, discusses some of the ideas in his  paper  ‘Factor one, familiarity and frontal cortex: a challenge to the two-factor theory of delusions’ recently published in the Journal of Cognitive Neuropsychiatry. Over recent years, Imperfect Cognitions has become the premier hub and outlet for work on the neurobiology and cognitive psychology of delusions. It has featured my work on aberrant prediction error and delusions in schizophrenia (Corlett et al., 2007 ), and work that conceptually replicates it (Kaplan et al., 2016 ). There has been work, also highlighted on the blog, from neurological patients that suggest instead that a 2-factor explanation of delusions may be more appropriate (Darby et al., 2017 ), although that work was not conclusive (McKay and Furl, 2017 ). It has all garnered much interest. Partly because delusions inherently fascinating, I think, and partly because the argum...